Last update: 5/07/22 Connect with us:

The 8th European Workshop on Lipid Mediators “A Marcus Wallenberg symposium” will be held on June 29th - July 1st, 2022. It will be a face to face congress with real coffee breaks, sponsor stands, dinner at the Vasa Museum and real speakers!



Scientific Program

Young Investigator Symposium, Poster Awards and Travel Support

Registration & Abstract Submission

All the sponsors

Venue Photos-Map

Travel Informationn

Hotel Reservation

Committees and Contact

Past-Workshops on Lipid Mediators




8th European Workshop on Lipid Mediators (8EWLM)
‘A Marcus Wallenberg symposium’

Karolinska Institute, Stockholm, Sweden
June 29th - July1st, 2022


Educational SESSION

09:00 Opening address by Per-Johan Jakobsson and Marina Korotkova

09:05 - 09:30 Chengcan Yao   (20 + 5 min Q&A)
An update of PGE 2 ’s roles in mucosal inflammation

09:30 - 09:55 Cécile Gladine   (20 + 5 min Q&A)
Inter-individual variability of the circulating oxylipin profiles in humans: major determinants and consequences in clinical research

09:55 - 10:20 Craig Wheelock   (20 + 5 min Q&A)
Oxylipin metabolic profiling for identifying sub-phenotypes of obstructive lung disease

10:20 - 10:45 Ralf Morgenstern   (20 + 5 min Q&A)  
Enzyme kinetics, in practice


1st Sponsored SESSION
PGI2  analogues from bench to bedside

11:15 - 11:20  Welcome by chairpersons Xavier Norel and Lucie Clapp

11:20 - 11:45 Lucie Clapp   (University College London, UK) (20 + 5 min Q&A)
Multiple cellular targets for prostacyclin (IP) receptor agonists; therapeutic implications in pulmonary hypertension

11:45 - 12:10 Olivier Sitbon   (AP-HP, Hôpital Bicêtre, Univ. Paris-Sud, France, 20 + 5 min Q&A)
Therapeutic use of prostacyclin in pulmonary hypertension

12:10 - 12:30 Hichem Badji (Univ. Paris Cité - Hôpital X. Bichat, France, 15 + 5 min Q&A)
Comparative role of prostacyclin in the relaxation induced by ATP and ACh in pulmonary arteries from patients with or without pulmonary hypertension.

12:30 - 12:50 Samsul Arefin (Karolinska Univ. Hospital, Stockholm, Sweden, 15 + 5 min Q&A)
Effects of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition on resistance artery tone in patients with end stage kidney disease.


2nd Sponsored SESSION
Resolution of Inflammation

14:00 - 14:05  Welcome by chairpersons Sven-Erik Dahlén and Olof Rådmark

14:05 - 14:45 Charles Serhan   (Brigham and Women's Hospital-Harvard Medical School, Boston, US) (35 + 5 min Q&A)
Pro-resolving lipid mediators are novel signals for tissue regeneration

14:45 - 15:15 Marc Dubourdeau   ( Ambiotis SAS, Toulouse, France) (25 + 5 min Q&A)
Resolution lipid signature in different physiological and pathological contexts

15:15 - 15:45 Dieter Steinhilber (Goethe Universität, Frankfurt, Germany) (25 + 5min) Pro-resolving lipid mediator formation in leukocytes

15:45 - 16:15 Final discussions – Moderators: Sven-Erik Dahlén, Olof Rådmark

17:45 Opening Reception in Stockholm City Hall (please be on time) - See the beautiful venue of the Nobel Banquet, hosted by Stockholm City and Region Stockholm, including a drink andd snacks


 9:00 - 9:05 – Welcome by Per-Johan Jakobsson

09:05-09:45  Opening Plenary Lecture

Jesper Z Haeggström   ( Karolinska Institutet, Sweden) (30 + 10 min Q&A)
The leukotriene cascade, molecular mechanisms and therapeutic opportunities

SESSION 1. 09:45 – 12:45
Lipid mediator research at the Karolinska Institutet

Chairperson: Olof Rådmark

9:45 - 10:10 Magnus Bäck (20 + 5 min Q&A)
Receptors for pro-resolving mediators in atherosclerosis

10:10 - 10:35 Sven-Erik Dahlén   (20 + 5 min Q&A)
Lipid mediators in asthma and NSAID intolerance

10:35 - 10:55 Johan Kolmert   (15 + 5 min Q&A)
Molecular phenotyping of asthma using urinary eicosanoid biomarkers

  COFFEE BREAK (+ poster viewing and Sponsor stands visit)

11:25 - 11:45 Per-Johan Jakobsson & Charlotte Edenius (15+ 5 min Q&A)
mPGES-1 background and phase I trial

11:45 - 12:45
Karin Larsson
  – mPGES-1 in cancer
Eric Herlenius   – Inflammation, apnea and inspiration
Julia Esser-von Bieren – Eicosanoids as mediators of trained immunity in airway disease
Craig Wheelock   – "Not just fat" – Exploring Octadecanoids as Novel Bioactive Lipids in Inflammation

SESSION 2. 13:50 -15:45
Enzymatic formation, receptors and signal transduction

13:50 - 13:55  Welcome by chairpersons Giulio Muccioli and Cristina López-Vicario

13:55 - 14:20 Oliver Werz   (Friedrich-Schiller-University Jena, Germany) (20 min + 5 min Q&A)
Natural products that promote the lipid mediator class switch in inflammation

14:20 - 14:45 Takao Shimizu (University of Tokyo, Japan) (20 min + 5 min Q&A)
Roles of PUFAs in vivo: from mediators to membrane

14:45 - 15:05 Christian Reynolds (Wayne State University School of Medicine, USA) (15 + 5 min Q&A)
Excessive Dietary Linoleic Acid Promotes Plasma Accumulation of Pronociceptive Lipid Mediators and Thermal Nociceptive Hypersensitivity

15:05 - 15:25 Andrea Szuchman-Sapir (MIGAL - Galilee Research Institute, Israel) (15 + 5 min Q&A)
Molecular regulation of endothelial and vascular dysfunction by PUFA-derived lactone mediators

15:25 - 15:45 Nils Schebb (University of Wuppertal, Germany) (15 + 5 min Q&A)
Performance and limitation of state-of-the-art quantitative analysis for specialized proresolving mediators

COFFEE BREAK (+ poster viewing and Sponsor stands visit)

SESSION 3. 16:05 - 18:00
Lipid mediator classes and structural chemistry

16:05 - 16:10 – Welcome by chairpersons Craig Wheelock and Gerard Bannenberg

16:10 - 16:35 Joost CM Holthuis   (University of Osnabrück, Germany) (20 + 5 min Q&A)
Molecular dissection of ceramide-induced apoptosis using light-driven lipid probes

16:35 - 17:00 Trond Vidar Hansen   (University of Oslo, Norway) (20 + 5 min Q&A)
Elucidation of the biosynthetic pathways of the protectins

17:00 - 17:20 Markus Werner (Friedrich Schiller University Jena, Germany) (15 + 5 min Q&A)
Transcellular metabolism in binary cell incubations differentially affects SPM biosynthesis

17:20 - 17:40 Eugen Proschak (Goethe-University Frankfurt, Germany) (15 + 5 min Q&A)
Chemical Probes for Targets in Lipid Signalling

17:40 - 18:00 Jesper Säfholm (Karolinska Institutet, Biomedicum, Sweden) (15 + 5 min Q&A)
Functional characterisation of mast cell activation by IgE and hyperosmolarlarity in isolated human small airways

19:30 Dinner at the Vasa Museum – including a guided tour
Bus transport will be provided from Carolina Tower, Elite Palace and Scandic Norra Bantorget


09:00 - 09:05  Morning address  by Chengcan Yao

09:05 - 09:45 Plenary session

Garret A. FitzGerald   (University of Pennsylvania, USA) (30 min + 10 min Q&A)
Bioactive Lipids in the Pandemic World

 SESSION 4. 09:45 - 12:10
Therapeutic approaches including resolution – I

09:45 - 09:50 Welcome by chairpersons Xavier Norel and Cristina López-Vicario

09:50 - 10:15 Mauro Perretti  (Queen Mary University of London, UK) (20 + 5 min Q&A)
Pro-resolving lipid mediators and the control of arthritis

COFFEE BREAK (+ poster viewing and Sponsor stands visit)

10:45 - 11:10 Hanns-Ulrich Marschall (Sahlgrenska Academy, University of Gothenburg, Sweden) (20 + 5 min Q&A)
Bile acid metabolism and FXR-mediated effects

11:10 – 11:30 Edward Dennis (University of California at San Diego, USA) (15 + 5 min Q&A)
Specificity of Phospholipase A2s Regulate which Downstream PUFA-Derived Mediators Are Produced

11:30 – 11:50 Antonio Recchiuti (G. d'Annunzio University of Chieti, Italy) (15 + 5 min Q&A)
Resolvin D1 and D2 Reduce Inflammatory Response to SARS-COV-2

11:50 – 12:10 Meike Saul (Technische Universität Darmstadt, Germany) (15 + 5 min Q&A)
Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer



Chairpersons: Gerard Bannenberg and Mireille Alhouayek

(5 min + 3 min Q&A each, timed)

Franziska Hartung ( Technical University of Munich and Helmholtz Center Munich, Germany)
Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma

   Patrick Schädel (Friedrich-Schiller-University Jena, Germany)
Metabololipidomic and proteomic profiling reveals aberrant macrophage polarization and interrelated lipid mediator formation during aging

 Xiao Tang (Karolinska Institutet, Sweden)
Activation of SUCNR1 boosts human mast cell reactivity and allergic bronchoconstriction

Elodie Arel (Université de Montpellier, France)
Could NEO-DHA regulate macrophages?

Tarvi Teder (Karolinska Institutet, Sweden)
The IRE1alpha inhibitor KIRA6 blocks leukotriene biosynthesis in human phagocytes

Sina Bohnacker ( Technical University of Munich and Helmholtz Center Munich, Germany)
A helminth glutamate dehydrogenase targets eicosanoid pathways to modulate type-2 immunity

Denise Biagini ( University of Pisa, Italy)
A powerful oxylipidomics platform to study inflammation regulation in COVID-19

Johanna Revol-Cavalier (Karolinska Institutet, Sweden)
Multi-step syntheses of a new series of gut microbial octadecanoid metabolites and evaluation of their phagocytotic activity

Yuping Ning (Friedrich-Schiller-University Jena, Germany & Shenzhen University School of Medicine, China)
Mycobacterium tuberculosis-induced prostaglandin J2 inhibits inflammatory signals through TAK1-NFκB-MAPK pathway in M1 macrophages

Axel Nordström ( Sophiahemmet University, Sweden)
Levels of eicosanoids in nasal secretions and urine associated with nasal polyp severity in chronic rhinosinusitis

Paul Mike Jordan (Friedrich-Schiller-University Jena, Germany)
Alpha-Hemolysin from Staphylococcus aureus is a potent inducer of specialized pro- resolving mediator generation promoting inflammation resolution

COFFEE BREAK (+ poster viewing and Sponsor stands visit)

SESSION 5. 15.30 – 17.45
Therapeutic approaches including resolution – II

Chairpersons: Chengcan Yao and Sven-Erik Dahlén

15:30 - 15:55 Bruce D Levy   (Brigham and Women's Hospital and Harvard Medical School, USA) (20 + 5 min Q&A)
Towards Targeting Pro-Resolution Pathways of Inflammation in Airway Disease

15:55 - 16:20 Catherine Godson (University College, Dublin, Ireland) (20 + 5 min Q&A)
New tools in Resolving Inflammation and Suppressing Fibrosis

16:20 - 16:45 Jenny Mjösberg   (Karolinska Institutet, Stockholm) (20 + 5 min Q&A)
Lipid mediator regulation of ILC2 cells

16:45 - 17:05 Emanuela Ricciotti (University of Pennsylvania, USA) (15 + 5 min Q&A)
Cyclooxygenase-2 and heart failure with preserved ejection fraction

17:05 - 17:25 Amel Bouhadoun (Université Sorbonne Paris Nord - Hôpital X. Bichat, France) (15 + 5 min Q&A)
DHA, RvD1, RvD5 and MaR1 reduce human coronary arteries contractions induced by PGE2

17:25 - 17:45 Sven-Christian Pawelzik (Karolinska University Hospital, Sweden) (15 + 5 min Q&A)
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: a single-blind randomized controlled trial

Prize Winners and travel support announcements (Young session awards, Poster Prizes, etc)

18:00–18:15  Adjourn: Workshop closing address by Per-Johan Jakobsson and host for 9th EWLM.




Larodan morning jog!

The Special Issue of
our previous European
Workshop on Lipid
Mediators (Brussels Edition)
is now on-line


Our Sponsors:


Our Sponsors: