VII European Workshop on Lipid Mediators (7EWLM)

Université catholique de Louvain, Brussels, Belgium
September 12-14, 2018

WEDNESDAY, SEPTEMBER 12

EDUCATIONAL SESSION

THURSDAY, SEPTEMBER 13

08:00-08:55 Registration. Coffee.

08:55-09:00 Morning address by organizers

09:00-09:45 Opening plenary lecture
Timothy Hla (Children’s Hospital, Boston)
Chaperone-dependent S1P signaling

Session 1. LIPID MEDIATOR RECEPTORS AND SIGNALING
Chairpersons: Xavier Norel (INSERM U1148, France) / Per-Johan Jakobsson (Karolinska Institutet, Sweden)

09:45-10:15 Dieter Steinhilber (Goethe University, Germany)
The 5-lipoxygenase pathway in cancer (25 +5 min Q&A)
10:15-10:45 Sandra Donnini (University of Siena, Italy)
Prostaglandins in cancer progression (25 +5 min Q&A)

10:45-11:15 Coffee Break: Poster session and Exhibition visit

11:15 -11:40 Yukihiko Sugimoto (Kumamoto University, Japan)
Stimulation and modulation of inflammatory mast cell responses by prostaglandin receptors (20 +5 min Q&A)
11:40-12:05 Amira Senbel (Alexandria University, Egypt)
Contraction induced by EP1 receptors activation in rat detrusor muscle is counteracted by the NO/cGMP pathway (20 +5 min Q&A)
 12:05-12:30 Karin Larsson (Karolinska Institute , Sweden)
Selective inhibition of PGE2 enhances the cytotoxic effect of doxorubicin and vincristine in multicellular tumor spheroids (20 +5 min Q&A)

12:30-14:10 Lunch

Session 2. LIPID MEDIATORS IN IMMUNE AND INFLAMMATORY RESPONSES
Chairpersons: Chengcan Yao (University of Edinburgh, UK) / Mireille Alhouayek (Université catholique de Louvain, Belgium)

14:10-14:40 Renger Witkamp (Wageningen University, The Netherlands)
From fish to cannabis – modulation of inflammation by n-3 PUFAs (25 +5 min Q&A)
14:40-15:10 Jon Lampa (Karolinska Institute, Sweden)
Role of prostaglandins in neuro-immune regulation (25 +5 min Q&A)

15:10-15:35 Shuntaro Hara (Showa University, Japan)
Regulation of Inflammatory Prostaglandin Synthesis by Acyl-CoA Synthetase ACSL4 (20 +5 min Q&A)
15:35-16:00 Karsten Weyland (Brandenburg Medical School, Germany)
ALOX15-deficiency: a two-edged sword in colitis (20 +5 min Q&A)
16:00-16:25 Romain Colas (Queen Mary University of London, UK)
Cerebrospinal Fluid Pro-resolving Mediators Correlate with Disease Severity and Outcome in Adults with Tuberculosis Meningitis (20 +5 min Q&A)

16:25-17:10 Coffee Break: Poster session and Exhibition visit

Session 3. LIPID MEDIATORS IN VASCULAR AND METABOLIC DISEASES
Chairpersons: Xavier Norel (INSERM U1148, France) / Joan Clària (Hospital Clínic-IDIBAPS, Spain)

17:10-17:40 Jean-Luc Cracowski (INSERM UMR 1042 , Grenoble, France)
Targeting the prostacyclin pathway: beyond pulmonary arterial hypertension (25 +5 min Q&A)
17:40-18:10 Jane Mitchell (Imperial College London, UK)
COX-2 and prostanoid pathways in the cardiorenal system: mechanisms and biomarkers (25 +5 min Q&A)

18:10-18:22 Hasanga Manik Purage (INSERM, U1148, Paris, France)
PGI2 induced relaxations overcome the PGE2 induced vasoconstrictions in human coronary artery (10 +2 min Q&A)
18:23-18:35 Zsuzsanna Miklos (Semmelweis University, Hungary)
Lysophosphatidic acid induces strong vasoconstriction in the coronaries via multiple signalling pathways (10 +3 min Q&A)
18:35-19:00 Sven-Christian Pawelzik (Karolinska University Hospital Solna , Sweden)
Transcriptomic and lipidomic profiling of human heart valves reveal a specific prostaglandin E2 signature in calcific aortic stenosis (20 +5 min Q&A)

Closing Remarks for Day 1 Organizer, affiliation / Organizer, affiliation

Gala Dinner (20:00)

FRIDAY, SEPTEMBER 14

8:30-9:15 Plenary lecture
Thierry Durand (University of Montpellier, France)
Isoprostanes, Phytoprostanes, Neuroprostanes: Biomarkers and Bioactive Lipids

YOUNG INVESTIGATOR SESSION
Chengcan Yao (Edinburgh University) / Gerard Bannenberg (Global Organization for EPA and DHA omega-3s)

9:15-11:15 13 junior speakers, 7+2 min Q&A.

Session 4. ENDOCANNABINOIDS
Chairpersons: Chairpersons: Giulio Muccioli (Université catholique de Louvain, Belgium) / Mireille Alhouayek (Université catholique de Louvain, Belgium)

11:45-12:15 Christopher Fowler (Umea University, Sweden)
The endocannabinoid system in cancer - beneficial or damaging? (25 +5 min Q&A)
12:15-12:45 Sophie Lotersztajn (INSERM UMR 1149, Paris, France)
The endocannabinoid system in the liver: novel perspectives (25 +5 min Q&A)

12:45-13:10 Mireille Alhouayek (Université catholique de Louvain, Belgium)
Prostaglandin D2-glycerol ester, a COX-2 metabolite of 2-arachidonoylglycerol, decreases inflammatory pain in mice (20 +5 min Q&A)
13:10-13:35 Wen Hui Wang (New York Medical College, USA)
Eicosaepoxytrienoic acid metabolites (EET) regulate kidney sodium transport (20 +5 min Q&A)

13:35-15:00 Lunch

15:00-15:30 Awards ceremony

Session 5. LIPIDOMICS AND ADVANCES IN FATTY ACIDS AND THEIR DERIVATIVES
Chairpersons: Nils Helge Schebb (University Wuppertal, Germany) / Gerard Bannenberg (Global Organization for EPA and DHA omega-3s)

15:30-16:00 Jesmond Dalli (William Harvey Research Institute, UK)
Functional Lipid Mediator Profiling in Establishing Disease Etiopathogenesis (25 +5 min Q&A)
16:00-16:30 William Griffiths (Swansea University, UK)
Lipidomics, Oxysterols and Lipid Mediators (25 +5 min Q&A)

16:30 -16:55 Esther Titos (Hospital Clínic-IDIBAPS, Barcelona, Spain)
Plasma lipidomic profiling and adipose tissue kinomics link arachidonic acid derived metabolites to MAP kinase activation in human obesity (20 +5 min Q&A)
16:55-17:20 Stefanie Liening (Friedrich-Schiller-University of Jena, Germany)
Development of a liquid chromatography coupled mass spectrometry analysis of glutathione conjugates of polyunsaturated fatty acids (20 +5 min Q&A)
17:20-17:45 Cristina Lopez-Vicario (Hospital Clínic-IDIBAPS, Barcelona, Spain)
Leukocytes from obese individuals exhibit an impaired SPM biosynthetic signature (20 +5 min Q&A)

17:45 Adjourn: Workshop closing address by organizers

(Coffee and beverages for last stayers)

In italic the speakers selected from the submitted abstracts