October 23

8:00-9:00 Registration, Coffee

9:05-9:15 Opening address by organizers

Opening lecture

9:15-10:00 Yukihiko Sugimoto (Kumamoto University, Japan)
Prostaglandin E2 – EP3 signaling triggers acute inflammation by mast cell activation

Session 1. PGE₂ IN PATHOPHYSIOLOGY

Chairpersons: Per-Johan Jakobsson (Karolinska Institutet, Stockholm, Sweden) and Jane Mitchell (Imperial College, London, UK)

10:00-10:30 Chengcan Yao (The University of Edinburgh, The Queen’s Medical Research Institute, MRC Centre for Inflammation Research, UK)
Prostaglandin E₂ and T-cell mediated inflammation(25 +5 Q&A)

10:30 -11:00 Helen Wise (Chinese University of Hong Kong, China)
Neuroinflammation: role of PGE₂ in neuron-glial interactions (25 +5 Q&A)

11:00-11:30 Coffee Break - Poster session and Exhibition visit 

11:30 -12:00 Jean-Etienne Fabre (IGBMC, INSERM U596, CNRS UMR7104, Université Louis Pasteur, Illkirch, France)
Implications of the unexpected role of PGE₂ in atherothrombosis (25 +5 Q&A)

12:00-12:20 Shuntaro Hara* (Showa University, Tokyo, Japan)
Involvement of microsomal prostaglandin E synthase-1 - derived prostaglandin E₂ in chemical-induced carcinogenesis (15 +5 Q&A)

12:20-12:40 Tomoaki Inazumi* (Kumamoto University, CREST, JST, Japan)
Role of prostaglandin EP4 receptor in adipose tissue (15 +5 Q&A)

12:40-14:10 Lunch

Session 2. PROSTAGLANDINS AND CARDIOVASCULAR SYSTEM
Chairpersons: Xavier Norel (INSERM U1148, Paris, France) and Jane Mitchell (Imperial College, London, UK)

14:10-14:40 Therese Kinsella (University College, Dublin, Ireland)
Platelets and vascular cells, prostacyclin and thromboxane receptors (25 +5 Q&A)

14:40 -15:10 Paola Patrignani (University Chieti, Italy)
The role of platelets in cardiovascular disease and cancer (25 +5 Q&A)

15:10 -15:40 Karsten Schrör (Heinrich-Heine University, Düsseldorf, Germany)
Aspirin and lipid mediators in the circulatory system (25 +5 Q&A)

15:40-16:00 Stefan Chlopicki* (Jagiellonian University, Krakow, Poland)
1-Methylnicotinamide, a major metabolite of nicotinamide exerts anti- atherosclerotic action in ApoE/LDLR-/- mice; a possible involvement of COX-2/PGI₂ pathway (15 +5 Q&A)

16:00-16:20 Makoto Arita*(RIKEN Center for IMS, Yokohama, Kanagawa, Japan)
Genetic and lipidomic approach to uncover cardioprotective mechanisms by omega-3 polyunsaturated fatty acids (15 +5 Q&A)

16:20-16:50 Coffee Break : Poster session and Exhibition visit 

Session 3. NOVEL LIPID MEDIATORS AND ADVANCES IN LIPID MEDIATOR ANALYTICS
Chairpersons: Gerard Bannenberg (Global Organization for EPA and DHA, Madrid, Spain) and Öner Süzer (İstanbul Üniversitesi Cerrahpaşa, Turkey)

16:50-17:20 Jesús Balsinde (CSIC, Valladolid, Spain)
Lipid signaling and lipidomics in innate immunity and inflammation (25 +5 Q&A)

17:20 -17:50 Rob Vreeken (Netherlands Metabolomics Centre, Leiden, The Netherlands & Discovery & Exploratory BA, Discovery Sciences, Janssen Pharmaceutica NV, Beerse, Belgium)
High-resolution lipidomics (25 +5 Q&A)

17:50-18:10 David Slatter* (Cardiff university School of Medicine, UK)
Oxidized phospholipids from lipoxygenase significantly enhance tissue factor dependent thrombin generation in vitro (15 +5 Q&A)

18:10-18:30 Joanna B Strosznajder* (Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland)
The novel insight on the role of sphingosine-1-phosphate in neurodegeneration/ neuroprotection (15 +5 Q&A)

Closing Remarks for Day 1

Reception at the Foyer of the Heritage Building of the Faculty of Pharmacy

October 24

8:25-8:30 Morning address by organizers

Plenary lecture

8:30-9:15 Sven-Erik Dahlén (Karolinska Institutet, Stockholm, Sweden)
Roles of leukotrienes and other lipid mediators in asthma and allied airway diseases

Young Investigator Session
Chairpersons: Gerard Bannenberg (Global Organization for EPA and DHA, Madrid, Spain) and Gokce Topal (Faculty of Pharmacy, Istanbul University, Turkey)

9:15-11:15 10 junior speakers, 10 +2 min Q&A. See Selected Presentations

 

11:15-11:45 Coffee Break: Poster session and Exhibition visit

Session 4. LIPOXYGENASES
Chairpersons: Dieter Steinhilber (Universitaet Frankfurt, Germany) and  Zeliha Yazici (Cerrahpasa Faculty of Medicine, Istanbul, Turkey)  

11:45-12:15 Magnus Bäck (Karolinska Institute, Stockholm, Sweden)
5-Lipoxygenase and cardiovascular disease (25 +5 Q&A)

12:15 -12:45 Hartmut Kühn (Charité, Berlin, Germany)
15-Lipoxygenase; structure and function (25 +5 Q&A)

12:45-13:05 Hans-Erik Claesson* (Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden)
15-lipoxygenase: a novel drug target for treatment of inflammatory lung diseases (15 +5 Q&A)

13:05-13:25 Françoise Stanke-Labesque* (Université Grenoble Alpes; INSERM U1042, CHU, Grenoble, France)
Leukotrienes: key mediators of early vascular remodelling in obstructive sleep apnea syndrome. A translational approach (15 +5 Q&A)

13:25-15:25 Lunch (followed by coffee at poster session)

 Session 5. ADIPOSE TISSUE AND BIOACTIVE LIPIDS
Chairpersons: Joan Clària (Hospital Clínic/IDIBAPS) and Sönmez Uydeş Doğan (Faculty of Pharmacy, Istanbul University, Turkey)

15:25-15:55 Johan van de Voorde (Ghent University, Belgium)
Regulation of vascular tone by adipocytes (25 +5 Q&A)

15:55 -16:25 Ebru Erbay (Bilkent University, Ankara, Turkey)
Nutritional modification of lipotoxic endoplasmic reticulum stress and
inflammation by a bioactive lipokine prevents atherosclerosis (25 +5 Q&A)

16:25 -16:55 María Jesús Moreno Aliaga ( University of Navarra, Pamplona, Spain)
Role of omega-3 fatty acids in obesity, metabolic syndrome and cardiovascular diseases (25 +5 Q&A)

16:55-17:15 Jan Kopecky* (Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic)
Potential role of lipid mediators in the induction of fatty acids cycling an energy expenditute in white adipocytes (15 +5 Q&A)

17:15-17:35 Nils Helge Schebb* (University of Veterinary Medicine Hannover, Germany)
One week oral treatment of rats with soluble epoxide hydrolase inhibitor tppu– resulting drug levels and modulation of oxylipin pattern (15 +5 Q&A)

17:35-17:55 Mehmet Melli* (Ankara University, School of Medicine, Turkey)
Impact of colonic mucosal lipoxin A4 synthesis capacity on healing in rats with dextran sodium sulphate-induced colitis (15 +5 Q&A)

17:55 Adjourn : Workshop closing address by organizers

(Coffee and beverages for last stayers)

* indicates presentation selected from submitted abstracts