08:00-09:00 Registration

09:00-09:15 Opening address by organizers – Otto Stern Zentrum, Campus Riedberg, Lecture Hall H2

 Collaborative Research Centre sessions

 

Session A. LIPID MEDIATORS AND RESOLUTION OF INFLAMMATION

Chairpersons: Bernhard Brüne / Dieter Steinhilber (Goethe University Frankfurt)

09:15-09:45 Hartmut Kühn (Charité Berlin, Germany)

The role of ALOX15 in the biosynthesis of pro-resolving inflammatory mediators (25min +5 Q&A)

09:45 -10:05 Klaus Scholich (Goethe University Frankfurt, Germany)

Platelet-derived thromboxane promotes proinflammatory macrophage phenotypes during inflammation (15min +5 Q&A)

 10:05-10:40 Coffee Break

 10:40 -11:00 Dieter Steinhilber (Goethe University Frankfurt, Germany)

5-Lipoxygenase and cancer – where are the links? (15min +5 Q&A)

11:00-11:20 Cecile Gladine (INRA, Human Nutrition Research Unit, France)

Omega-3 fatty acid-derived oxylipins reduce inflammation response in human macrophages: putative mechanism through PPAR-gamma binding (15min +5 Q&A)

11:20-11:40 Andreea Ioan-Facsinay (University Medical Center Leiden , The Netherlands)

The omega-6 fatty acid adrenic acid acts as a pro-resolving mediator (15min +5 Q&A)

11:40-12:10 Derek W Gilroy (University College London, UK)

Resolution of acute inflammation and innate immune conditioning (25min +5 Q&A)

12:10-14:10 Lunch and CRC poster session (POSTER SCHEDULE)

 

Session B. SPHINGOLIPIDS

Chairpersons: Josef Pfeilschifter / Dagmar Meyer zu Heringdorf (Goethe University Frankfurt)

 14:10-14:40 Sibylle Schneider-Schaulies (University of Würzburg, Germany)

Sphingomyelinases regulating T cell activation and modulation by a pathogen (25min +5 Q&A)

14:40 -15:10 Andrea Huwiler (University of Bern, Switzerland)

The yin and yang of S1P in a fibrotic cell response (25min +5 Q&A)

15:10 -15:30 Georgios Grammatikos (Goethe University Frankfurt, Germany)

Sphingolipids as potential biomarkers of hepatic fibrosis and hepatocellular carcinoma (15min +5 Q&A)

15:30-15:50 Anja Schwiebs (Goethe University Frankfurt, Germany)

Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1 (15min +5 Q&A)

15:50-16:10 Robinson Daniel (Northwestern University Feinberg , Chicago , USA)

Long chain fatty acids and their related oxylipins in preterm human milk during the first month of lactation. (15min +5 Q&A) 

16:10-16:40 Coffee Break and Exhibition Visit

  

Session C. CYTOCHROME P450 PATHWAYS AND SOLUBLE EPOXIDE HYDROLASE

Chairpersons: Ingrid Fleming / Eugen Proschak (Goethe University Frankfurt)

 16:40-17:10 John Imig (Medical College of Wisconsin, Milwaukee, USA)

Soluble Epoxide Hydrolase & Novel Therapeutic Vistas (25min +5 Q&A)

17:10 -17:40 Ingrid Fleming (Institute for Vascular Signalling, Goethe University Frankfurt, Germany)

Looking good? The soluble epoxide hydrolase in the retina (25min +5 Q&A)

17:40-18:00 Eugen Proschak (Goethe University Frankfurt, Germany)

Discovery of chemical tools for investigation of the phosphatase activity of soluble epoxide hydrolase (15min +5 Q&A)

18:00-18:20 Anne Konkel (OMEICOS Therapeutics GmbH, Berlin, Germany)

Omega-3 epoxyeicosanoids – from bench to bedside (15min +5 Q&A)

18:20-21:00 Welcome reception at Otto-Stern-Zentrum

 

Thursday, September 29
6th EUROPEAN WORKSHOP ON LIPID MEDIATORS – Day 1

08:00-08:30 Registration

Plenary lecture

 08:30-09:15 Bruce Hammock (University of California Davis, USA)

Epoxides of arachidonic acid and docosahexaenoic acid modulate inflammatory and neuropathic pain

 

Session 1. FAT TISSUE-DERIVED BIOACTIVE LIPIDS AND LIPID DROPLETS: PHYSIOLOGY AND PATHOPHYSIOLOGY / RESOLVING LIPID MEDIATORS

Chairpersons: Joan Claria (Hospital Clinic, Barcelona), Gökçe Topal (Istanbul University)

09:15-09:45 Daniel Closa (CSIC, Barcelona, Spain)

Halogenated lipids in the inflammatory processes; the case of acute pancreatitis (25min +5 Q&A)

09:45 -10:15 Enrique Claro (Universitat Autònoma de Barcelona, Barcelona, Spain)

Biogenesis and catabolism of lipid droplets during stress (25min +5 Q&A)

 10:15-10:50 Coffee Break

 10:50 -11:10 Karsten Weylandt (Charité Berlin, Germany)

Alox15-deficiency modulates colitis activity in murine colitis (15min +5 Q&A)

11:10-11:30 Trond Vidar Hansen (University of Oslo, Norway)

The novel lipid mediator PD1n-3 DPA: Structural elucidation, biosynthesis, bioactions and total organic synthesis (15min +5 Q&A)

11:30-11:50 Minna Holopainen (Finnish Red Cross Blood Service, Helsinki, Finland)

11:50-12:10 Valerie Urbach (Paris, France)

Resolvin D1 reduces IL-8 secretion, improves alveolar macrophage activity, restores airway surface liquid height and normalizes nasal potential difference in cystic fibrosis (15min +5 Q&A)

 12:10-14:10 Lunch and poster session I (POSTER SCHEDULE)

  

Session 2. PROSTAGLANDINS, LEUKOTRIENES AND n-3 PUFAs IN CANCER

Chairpersons: Gerard Bannenberg (GOED, Madrid) / Per Kogner (Karolinska Institute, Stockholm)

14:10-14:40 Per Kogner (Karolinska Institutet, Stockholm, Sweden)

Tumor promoting inflammation as therapeutic target in childhood cancer (25min +5 Q&A)

14:40 -15:10 Dipak Panigrahy (Beth Israel Hospital and Harvard Medical School, Boston, USA)

Omega-3 polyunsaturated fatty acid-derived pro-resolving lipid mediators in cancer (25min +5 Q&A)

15:10 -15:30 Nadine Rohwer (Charité, Berlin, Germany)

Low dose aspirin treatment inhibits mouse colon tumorigenesis and modifies the eicosanoid metabolome (15min +5 Q&A)

15:30-15:50 Shuntaro Hara (School of Pharmacy, Tokyo, Japan)

Role of prostaglandin terminal synthases PGIS and mPGES-1 in chemical-induced carcinogenesis (15min +5 Q&A)

15:50-16:10 Ulrike Garscha (Institute of Pharmacy, Jena, Germany)

5-Lipoxygenase-activating protein (FLAP) rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation (20min +5 Q&A)

16:10-16:40 Coffee Break and Exhibition Visit

 

Session 3. PROTEO-METABOLO-LIPIDOMICS

Chairpersons: Nils Helge Schebb (University of Wuppertal) / Nicolas Flamand (Quebec)

 16:40-17:10 Nerea Ferreiros (pharmazentrum, Goethe University Frankfurt, Germany)

Someone there? Handicaps for the detection of pro resolving lipid mediators (25min +5 Q&A)

17:10 -17:40 Stefan Offermanns (Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany)

Physiological and pathophysiological roles of short chain fatty acid receptors (25min +5 Q&A)

17:40-18:00 Pei-an Betty Shih (University of California, San Diego, USA)

Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa (15min +5 Q&A)

18:00-18:20 Andreas Koeberle (University of Jena, Germany)

Functional lipidomics reveals role of phospholipid-based lipid mediators in vitamin A signaling (15min +5 Q&A)

 

20:00 Conference Dinner at the Campus Westend, Goethe University Frankfurt,

Theodor-W.-Adorno-Platz 3, 60323 Frankfurt

Friday, September 30
6th EUROPEAN WORKSHOP ON LIPID MEDIATORS – Day 2

08:30-09:15 Opening lecture

 Bill Lands (Fellow, American Society for Nutrition, USA)

Relationship between essential fatty acid intake and lipid mediator biosynthesis and action

 

YOUNG INVESTIGATOR SESSION

Chairpersons: Jesús Balsinde (CSIC) / Joan Claria (Hospital Clinic, Barcelona)

09:15-11:15, 10 junior speakers, 10 x(10min +2 Q&A)

 11:15-11:50 Coffee Break and exhibition visit
 

Session 4. CYCLOOXYGENASE PATHWAY, PROSTACYCLIN AND PGE2 SYNTHESIS IN THE CARDIOVASCULAR SYSTEM

Chairpersons: Sönmez Uydes Dogan (Istanbul University) / Xavier Norel (INSERM U1148, Paris)

11:50-12:20 Nicolas Flamand (Université Laval, Québec City, Canada)

Regulation of human leukocyte functions by endocannabinoids and their metabolites (25min +5 Q&A)

12:20 -12:50 Akos Heinemann (University of Graz, Austria)

Role of prostaglandins in leukocyte trafficking (25min +5 Q&A)

12:50-13:10 Yao Chengcan (University of Edinburgh, Ireland)

Regulation of systemic inflammation by prostaglandin E2 (15min +5 Q&A)

13:10-13:30 Zoltan Benyo (Semmelweis University Budapest, Hungary)

Complex signaling pathways of thromboxane receptor mediated vascular smooth muscle contraction (15min +5 Q&A)

 13:30-15:30 Lunch and Poster Session II (POSTER SCHEDULE)

 

 Session 5. PHARMACEUTICALS BASED ON EICOSANOIDS / LIPID MEDIATOR PHARMACOLOGY AND RECEPTORS

Chairpersons: Per-Johan Jakobsson (Karolinska Institute Stockholm) / Nan Chiang (Boston)

15:30-16:00 Brendan Whittle (William Harvey Research Institute, London, UK)

Development of prostanoids as therapeutic agents for vascular disease (25min +5 Q&A)

16:00 -16:30 Nan Chiang (Brigham & Women’s Hospital and Harvard Medical School, Boston, USA)

Specialized Proresolving Mediators (SPM) as templates for resolution pharmacology (25min +5 Q&A)

16:30 -16:50 Daniel Merk (Goethe University Frankfurt, Germany)

Facing non-alcoholic steatohepatitis with FXR activation and sEH inhibition (15min +5 Q&A)

16:50-17:10 Johannes Hendrick von Hegedus (Leiden University Medical Center , The Netherlands)

Chronic Toll-like receptor signalling induces an temporal switch towards a more resolving lipid profile in monocyte-derived macrophages (15min +5 Q&A)

17:10-17:30 Joan Raouf (Karolinska Institute, Stockholm, Sweden)

mPGES-1 deletion increases prostacyclin and evades the elevated systemic ADMA associated with COX-2 inhibitors: relevance to cardiovascular safety of mPGES-1 (15min +5 Q&A)

 

17:30 Adjourn : Workshop closing address by organizers