8th European Workshop on Lipid Mediators (8EWLM)
‘A Marcus Wallenberg symposium’
Karolinska Institute, Stockholm, Sweden
June 29th - July1st, 2022
WEDNESDAY, JUNE 29th
Educational SESSION
09:00 – Opening address by Per-Johan Jakobsson and Marina Korotkova
09:05 - 09:30 Chengcan Yao (20 + 5 min Q&A)
An update of PGE 2 ’s roles in mucosal inflammation
09:30 - 09:55 Cécile Gladine (20 + 5 min Q&A)
Inter-individual variability of the circulating oxylipin profiles in humans: major determinants and consequences in clinical research
09:55 - 10:20 Craig Wheelock (20 + 5 min Q&A)
Oxylipin metabolic profiling for identifying sub-phenotypes of obstructive lung disease
10:20 - 10:45 Ralf Morgenstern (20 + 5 min Q&A)
Enzyme kinetics, in practice
COFFEE BREAK
1st Sponsored SESSION
PGI2 analogues from bench to bedside
11:15 - 11:20 – Welcome by chairpersons Xavier Norel and Lucie Clapp
11:20 - 11:45 Lucie Clapp (University College London, UK) (20 + 5 min Q&A)
Multiple cellular targets for prostacyclin (IP) receptor agonists; therapeutic implications in pulmonary hypertension
11:45 - 12:10 Olivier Sitbon (AP-HP, Hôpital Bicêtre, Univ. Paris-Sud, France, 20 + 5 min Q&A)
Therapeutic use of prostacyclin in pulmonary hypertension
12:10 - 12:30 Hichem Badji (Univ. Paris Cité - Hôpital X. Bichat, France, 15 + 5 min Q&A)
Comparative role of prostacyclin in the relaxation induced by ATP and ACh in pulmonary arteries from patients with or without pulmonary hypertension.
12:30 - 12:50 Samsul Arefin (Karolinska Univ. Hospital, Stockholm, Sweden, 15 + 5 min Q&A)
Effects of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition on resistance artery tone in patients with end stage kidney disease.
LUNCH BREAK
2nd Sponsored SESSION
Resolution of Inflammation
14:00 - 14:05 – Welcome by chairpersons Sven-Erik Dahlén and Olof Rådmark
14:05 - 14:45 Charles Serhan (Brigham and Women's Hospital-Harvard Medical School, Boston, US) (35 + 5 min Q&A)
Pro-resolving lipid mediators are novel signals for tissue regeneration
14:45 - 15:15 Marc Dubourdeau ( Ambiotis SAS, Toulouse, France) (25 + 5 min Q&A)
Resolution lipid signature in different physiological and pathological contexts
15:15 - 15:45 Dieter Steinhilber (Goethe Universität, Frankfurt, Germany) (25 + 5min) Pro-resolving lipid mediator formation in leukocytes
15:45 - 16:15 Final discussions – Moderators: Sven-Erik Dahlén, Olof Rådmark
17:45 Opening Reception in Stockholm City Hall (please be on time) - See the beautiful venue of the Nobel Banquet, hosted by Stockholm City and Region Stockholm, including a drink andd snacks
THURSDAY, JUNE 30th
9:00 - 9:05 – Welcome by Per-Johan Jakobsson
09:05-09:45 Opening Plenary Lecture
Jesper Z Haeggström ( Karolinska Institutet, Sweden) (30 + 10 min Q&A)
The leukotriene cascade, molecular mechanisms and therapeutic opportunities
SESSION 1. 09:45 – 12:45
Lipid mediator research at the Karolinska Institutet
Chairperson: Olof Rådmark
9:45 - 10:10 Magnus Bäck (20 + 5 min Q&A)
Receptors for pro-resolving mediators in atherosclerosis
10:10 - 10:35 Sven-Erik Dahlén (20 + 5 min Q&A)
Lipid mediators in asthma and NSAID intolerance
10:35 - 10:55 Johan Kolmert (15 + 5 min Q&A)
Molecular phenotyping of asthma using urinary eicosanoid biomarkers
COFFEE BREAK (+ poster viewing and Sponsor stands visit)
11:25 - 11:45 Per-Johan Jakobsson & Charlotte Edenius (15+ 5 min Q&A)
mPGES-1 background and phase I trial
11:45 - 12:45
Karin Larsson – mPGES-1 in cancer
Eric Herlenius – Inflammation, apnea and inspiration
Julia Esser-von Bieren – Eicosanoids as mediators of trained immunity in airway disease
Craig Wheelock – "Not just fat" – Exploring Octadecanoids as Novel Bioactive Lipids in Inflammation
SESSION 2. 13:50 -15:45
Enzymatic formation, receptors and signal transduction
13:50 - 13:55 – Welcome by chairpersons Giulio Muccioli and Cristina López-Vicario
13:55 - 14:20 Oliver Werz (Friedrich-Schiller-University Jena, Germany) (20 min + 5 min Q&A)
Natural products that promote the lipid mediator class switch in inflammation
14:20 - 14:45 Takao Shimizu (University of Tokyo, Japan) (20 min + 5 min Q&A)
Roles of PUFAs in vivo: from mediators to membrane
14:45 - 15:05 Christian Reynolds (Wayne State University School of Medicine, USA) (15 + 5 min Q&A)
Excessive Dietary Linoleic Acid Promotes Plasma Accumulation of Pronociceptive Lipid Mediators and Thermal Nociceptive Hypersensitivity
15:05 - 15:25 Andrea Szuchman-Sapir (MIGAL - Galilee Research Institute, Israel) (15 + 5 min Q&A)
Molecular regulation of endothelial and vascular dysfunction by PUFA-derived lactone mediators
15:25 - 15:45 Nils Schebb (University of Wuppertal, Germany) (15 + 5 min Q&A)
Performance and limitation of state-of-the-art quantitative analysis for specialized proresolving mediators
COFFEE BREAK (+ poster viewing and Sponsor stands visit)
SESSION 3. 16:05 - 18:00
Lipid mediator classes and structural chemistry
16:05 - 16:10 – Welcome by chairpersons Craig Wheelock and Gerard Bannenberg
16:10 - 16:35 Joost CM Holthuis (University of Osnabrück, Germany) (20 + 5 min Q&A)
Molecular dissection of ceramide-induced apoptosis using light-driven lipid probes
16:35 - 17:00 Trond Vidar Hansen (University of Oslo, Norway) (20 + 5 min Q&A)
Elucidation of the biosynthetic pathways of the protectins
17:00 - 17:20 Markus Werner (Friedrich Schiller University Jena, Germany) (15 + 5 min Q&A)
Transcellular metabolism in binary cell incubations differentially affects SPM biosynthesis
17:20 - 17:40 Eugen Proschak (Goethe-University Frankfurt, Germany) (15 + 5 min Q&A)
Chemical Probes for Targets in Lipid Signalling
17:40 - 18:00 Jesper Säfholm (Karolinska Institutet, Biomedicum, Sweden) (15 + 5 min Q&A)
Functional characterisation of mast cell activation by IgE and hyperosmolarlarity in isolated human small airways
19:30 Dinner at the Vasa Museum – including a guided tour
Bus transport will be provided from Carolina Tower, Elite Palace and Scandic Norra Bantorget
FRIDAY, JULY 1st
09:00 - 09:05 – Morning address by Chengcan Yao
09:05 - 09:45 Plenary session
Garret A. FitzGerald (University of Pennsylvania, USA) (30 min + 10 min Q&A)
Bioactive Lipids in the Pandemic World
SESSION 4. 09:45 - 12:10
Therapeutic approaches including resolution – I
09:45 - 09:50 –Welcome by chairpersons Xavier Norel and Cristina López-Vicario
09:50 - 10:15 Mauro Perretti (Queen Mary University of London, UK) (20 + 5 min Q&A)
Pro-resolving lipid mediators and the control of arthritis
COFFEE BREAK (+ poster viewing and Sponsor stands visit)
10:45 - 11:10 Hanns-Ulrich Marschall (Sahlgrenska Academy, University of Gothenburg, Sweden) (20 + 5 min Q&A)
Bile acid metabolism and FXR-mediated effects
11:10 – 11:30 Edward Dennis (University of California at San Diego, USA) (15 + 5 min Q&A)
Specificity of Phospholipase A2s Regulate which Downstream PUFA-Derived Mediators Are Produced
11:30 – 11:50 Antonio Recchiuti (G. d'Annunzio University of Chieti, Italy) (15 + 5 min Q&A)
Resolvin D1 and D2 Reduce Inflammatory Response to SARS-COV-2
11:50 – 12:10 Meike Saul (Technische Universität Darmstadt, Germany) (15 + 5 min Q&A)
Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer
LUNCH BREAK
YOUNG INVESTIGATOR SESSION 13:30 - 15:00
Chairpersons: Gerard Bannenberg and Mireille Alhouayek
(5 min + 3 min Q&A each, timed)
Franziska Hartung ( Technical University of Munich and Helmholtz Center Munich, Germany)
Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma
Patrick Schädel (Friedrich-Schiller-University Jena, Germany)
Metabololipidomic and proteomic profiling reveals aberrant macrophage polarization and interrelated lipid mediator formation during aging
Xiao Tang (Karolinska Institutet, Sweden)
Activation of SUCNR1 boosts human mast cell reactivity and allergic bronchoconstriction
Elodie Arel (Université de Montpellier, France)
Could NEO-DHA regulate macrophages?
Tarvi Teder (Karolinska Institutet, Sweden)
The IRE1alpha inhibitor KIRA6 blocks leukotriene biosynthesis in human phagocytes
Sina Bohnacker ( Technical University of Munich and Helmholtz Center Munich, Germany)
A helminth glutamate dehydrogenase targets eicosanoid pathways to modulate type-2 immunity
Denise Biagini ( University of Pisa, Italy)
A powerful oxylipidomics platform to study inflammation regulation in COVID-19
Johanna Revol-Cavalier (Karolinska Institutet, Sweden)
Multi-step syntheses of a new series of gut microbial octadecanoid metabolites and evaluation of their phagocytotic activity
Yuping Ning (Friedrich-Schiller-University Jena, Germany & Shenzhen University School of Medicine, China)
Mycobacterium tuberculosis-induced prostaglandin J2 inhibits inflammatory signals through TAK1-NFκB-MAPK pathway in M1 macrophages
Axel Nordström ( Sophiahemmet University, Sweden)
Levels of eicosanoids in nasal secretions and urine associated with nasal polyp severity in chronic rhinosinusitis
Paul Mike Jordan (Friedrich-Schiller-University Jena, Germany)
Alpha-Hemolysin from Staphylococcus aureus is a potent inducer of specialized pro- resolving mediator generation promoting inflammation resolution
COFFEE BREAK (+ poster viewing and Sponsor stands visit)
SESSION 5. 15.30 – 17.45
Therapeutic approaches including resolution – II
Chairpersons: Chengcan Yao and Sven-Erik Dahlén
15:30 - 15:55 Bruce D Levy (Brigham and Women's Hospital and Harvard Medical School, USA) (20 + 5 min Q&A)
Towards Targeting Pro-Resolution Pathways of Inflammation in Airway Disease
15:55 - 16:20 Catherine Godson (University College, Dublin, Ireland) (20 + 5 min Q&A)
New tools in Resolving Inflammation and Suppressing Fibrosis
16:20 - 16:45 Jenny Mjösberg (Karolinska Institutet, Stockholm) (20 + 5 min Q&A)
Lipid mediator regulation of ILC2 cells
16:45 - 17:05 Emanuela Ricciotti (University of Pennsylvania, USA) (15 + 5 min Q&A)
Cyclooxygenase-2 and heart failure with preserved ejection fraction
17:05 - 17:25 Amel Bouhadoun (Université Sorbonne Paris Nord - Hôpital X. Bichat, France) (15 + 5 min Q&A)
DHA, RvD1, RvD5 and MaR1 reduce human coronary arteries contractions induced by PGE2
17:25 - 17:45 Sven-Christian Pawelzik (Karolinska University Hospital, Sweden) (15 + 5 min Q&A)
Immunomodulation by intravenous omega-3 fatty acid treatment in older subjects hospitalized for COVID-19: a single-blind randomized controlled trial
Prize Winners and travel support announcements (Young session awards, Poster Prizes, etc)
18:00–18:15 Adjourn: Workshop closing address by Per-Johan Jakobsson and host for 9th EWLM.
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