SCIENTIFIC PROGRAM

September 27

9:10 Welcome by the Organizers (Xavier Norel)
Jesús Balsinde introduces 1st Lecture: Ed Dennis (University of California, San Diego, USA)
9.15-10:00 Eicosanoid lipidomics and omega-3 role in the innate immune and inflammatory response

SESSION 1 LIPIDOMICS (Chairs: Jesús Balsinde & Gerard Bannenberg)

10:00-10:30 Lipid mediator profiling as part of a systems-based approach to investigating inflammatory disease
Craig Wheelock (Karolinska Institutet, Stockholm, Sweden)
10:30-11:00 Identification and characterisation of esterified eicosanoids generated by immune cells using lipidomics approaches
Valerie O’Donnell (School of Medicine, Cardiff University, Cardiff, UK)

 11:00-11:30 Coffee Break

11:30-12:00 Novel analytical approaches for the quantitative and qualitative analysis of lipids in biofluids
Rob Vreeken (Netherlands Metabolomics Centre, Leiden University, Leiden, The Netherlands)
*12:00-12:20 Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits: Establishment of a multiplex HPLC ESI MS-MS method
Ralph Rühl (University of Debrecen, Hungary)
*12:20-12:40 Generation of lysophosphatidylinositol, an endogenous agonist for novel cannabinoid receptor GPR55, by intracellular phospholipase A1
Atsushi Yamashita (Teikyo University, Japan)

12:40-14:10 Lunch

SESSION 2 OMEGA-3 (Chairs: Joan Clària & Francis Berenbaum)

14:10-14:40 Transfer of essential fatty acids from aquatic to terrestrial ecosystems
Michail Gladyshev (Siberian branch of Russian Academy of Sciences, Krasnoyarsk, Russia)
14:40-15:10 Omega-3-derived lipid mediators counteract obesity-induced adipose tissue inflammation
Esther Titos (Hospital Clinic-CIBERehd, Barcelona, Spain)
15:10-15:40 Omega 3 and the aging brain: from epidemiological data to intervention studies in humans
Pascale Barberger-Gateau (Inserm, Université de Bordeaux, Bordeaux, France)
*15:40-16:00 Quantitative Profiling of Omega-6 and Omega-3 Eicosanoids by LCMSMS in Health and Disease
Cecil Pace-Asciak (The Hospital for Sick Children Research Institute, Toronto, Canada)
*16:00-16:20 Isoprostanes and Neuroprostanes, Metabolites of omega-6 and omega-3 PUFAs : Not only Biomarkers of Lipid Peroxidation
Thierry Durand (Institut des Biomolécules Max Mousseron, Montpellier, France)

 

16:20-16:50 Coffee Break

SESSION 3 RESOLUTION OF INFLAMMATION (Chairs: Joan Clària & Gerard Bannenberg)

16:50 -17:20 Pro-resolution lipids: gamekeepers turn poachers
Derek Gilroy (Centre for Clinical Pharmacology and Therapeutics, University College London, UK )
17:20-17:50 Macrophage remodeling during the resolution of inflammation
Amiram Ariel (University of Haifa, Haifa, Israel)
*17:50-18:10 Emerging roles of eosinophils and eosinophil-derived lipid mediators in acute inflammation and resolution
Makoto Arita (University of Tokyo, Japan)
*18:10-18:30 Method of identification and quantification of resolvin D5 in biological samples: application to an in vivo animal model for evaluation of inflammation
Marc Dubordeau (Ambiotis, Toulouse, France)

18:30-19:45 POSTER SESSION + Wine and Cheese

September 28

Francis Berenbaum introduces 1st Lecture: Per-Johan Jakobsson (Karolinska Institutet, Stockholm, Sweden)
8:30-9:15 Microsomal prostaglandin E synthase, a multifaceted drug target

YOUNG SESSION (Chairs: Lhousseine Touqui & Xavier Norel)

9:15-11:15: (10+2 min each Speakers)

*The endocannabinoid 2-arachidonoylglycerol controls macrophage activation through its oxidative metabolite prostaglandin 2-glycerol (PGD2-G)
Mireille Alhouayek (Université catholique de Louvain, Bruxelles, Belgium)
*Endogenous epoxygenases regulate endothelial cell TNFalpha secretion
Ara Askari (William Harvey Research Institute, University of London, UK)
* Comparison of the relaxations induced by PGI2 analogues (used clinically), in isolated human pulmonary vessels: role of the DP receptor
Chabha Benyahia (INSERM U698, Université Paris Nord, France)
*Simultaneous Activation of p38 and JNK by Arachidonic Acid Stimulates the Cytosolic Phospholipase A2-dependent Synthesis of Lipid Droplets in Human Monocytes
Carlos Guijas (Instituto de Biología y Genética Molecular, Valladolid, Spain)
*Lysophosphatidic acid acyltransferase 3 – the missing link between polyunsaturated fatty acids and fertility?
Andreas Koeberle (Friedrich-Schiller-University, Jena, Germany)
*A Regulatory Loop Between Desaturases and Omega-3 Fatty Acids Plays a Major Role in Non-Alcoholic Steatohepatitis
Cristina López-Vicario (University of Barcelona, Spain)
* Mechanisms of P. aeruginosa-induced expression of secretory phospholipase A2 type IIA in cystic fibrosis lung epithelial cells
Erwan Pernet (INSERM U874, Institut Pasteur, Paris, France)
* Resolvin D1 activates Specific GPCRs and regulates miRNAs in novel resolution circuits
Antonio Recchiuti (Harvard Institutes of Medicine, Boston, USA)
*Adipocytes modulate the phenotype of macrophages through secreted lipids
Inge Klein-Wieringa (Leiden University Medical Center, The Netherlands)
*Investigating the Role of Cyclooxygenase in Toll-Like Receptor Responses
William Wright (Imperial College, London, UK)

11:15-11:45 Coffee Break

SESSION 4 INNATE IMMUNITY (Chairs: Lhousseine Touqui & Francis Berenbaum)

11:45-12:15 Lipids, apoptosis, and immunity to tuberculosis
Samuel M Behar (Harvard Medical School, Boston, USA)
12:15-12:45 Role of lipid mediators in airway inflammation
Massimo Triggiani (University of Naples, Naples, Italy)
*12:45-13:05 Adipocytes modulate T cell function through release of lipids
Andreea Ioan-Facsinay (Leiden University Medical Center, The Netherlands)
* 13:05-13:25 Elevated prostaglandin E2 mediates immune suppression in liver cirrhosis
Alastair O'Brien (University College London, United Kingdom)

 13:25-15:25 Lunch + POSTER SESSION

SESSION 5 PROSTANOID RECEPTOR PHARMACOLOGY (Chairs: Xavier Norel & Robert Jones)

15:25-15:55 Prostacyclin analogs in pulmonary hypertension
Lucie Clapp (Metabolism and Experimental Therapeutics, University College London, London, UK)
15:55-16:25 The pharmacology and therapeutic application of COX-2 metabolites of mammalian endocannabinoids
David Woodward (Allergan, Department of Biological Sciences, Irvine, CA, USA)
16:25-16:55 Prostanoid receptors in chronic inflammation
Shuh Narumiya (Department of Pharmacology, Kyoto University, Kyoto, Japan)
*16:55-17:15 Investigation of the slow kinetics of a non-prostanoid EP2 receptor agonist
Robert Leslie Jones (University of Strathclyde, UK)
* 17:15-17:35 The arachidonic acid epoxygenase: functional roles and relevance to the pathophysiology of hypertension and tumor angiogenesis
Jorge Capdevila (Vanderbilt University Medical School, Nashville, USA)

 17:35 Adjourn (Closing Remarks Joan Clària & Gerard Bannenberg)
last Coffee Break

*indicates a communication selected from the submited abstracts